Total Synthesis of Longeracinphyllin A

JacsTotal Synthesis of Longeracinphyllin A: The first and asymmetric total synthesis of longeracinphyllin A, a hexacyclicDaphniphyllum alkaloid, has been accomplished. A tetracyclic intermediate was prepared through silver-catalyzed alkyne cyclization and Luche radical cyclization. A phosphine-promoted [3 + 2] cycloaddition reaction was exploited to construct the sterically congested E ring bearing vicinal tertiary and quaternary centers.

Source: Organometallic Current - October 25, 2017 Category: Chemistry Tags: Total synthesis Source Type: blogs