Catalytic Asymmetric Synthesis of Quaternary Barbituric Acids

In this study 2-alkylthio-4,6-dioxopirimidines are designed as key 1,3-diamide surrogates that perfor m exceedingly in amine-squaramide catalyzed C–C bond forming reactions with vinyl ketones or Morita–Baylis–Hillmann-type allyl bromides as electrophiles.

Source: Organometallic Current - October 25, 2017 Category: Chemistry Tags: Asymmetric Source Type: blogs