Cobalt-Catalyzed Asymmetric Sequential Hydroboration/Hydrogenation of Internal Alkynes

JacsCobalt-Catalyzed Asymmetric Sequential Hydroboration/Hydrogenation of Internal Alkynes: A highly regio- and enantioselective cobalt-catalyzed hydroboration/hydrogenation of internal alkynes with HBpin and a hydrogen balloon in one pot was developed. A new type of chiral imidazoline iminopyridine (IIP) ligand was introduced for the first time in this novel and efficient strategy. This protocol used relatively simple and available starting materials with good functional group tolerance to construct more valuable chiral secondary organoboronates.

Source: Organometallic Current - October 25, 2017 Category: Chemistry Tags: Co catalyzed Hydroboration Hydrogenation Source Type: blogs