Verbal working memory and functional large-scale networks in schizophrenia

The aim of this study was to test whether bilinear and nonlinear effective connectivity (EC) measures of working memory fMRI data can differentiate between patients with schizophrenia (SZ) and healthy controls (HC). We applied bilinear and nonlinear Dynamic Causal Modeling (DCM) for the analysis of verbal working memory in 16 SZ and 21 HC. The connection strengths with nonlinear modulation between the dorsolateral prefrontal cortex (DLPFC) and the ventral tegmental area/substantia nigra (VTA/SN) were evaluated.

Source: Psychiatry Research: Neuroimaging - October 23, 2017 Category: Psychiatry Authors: Maria R Dauvermann, Thomas WJ Moorhead, Andrew R Watson, Barbara Duff, Liana Romaniuk, Jeremy Hall, Neil Roberts, Graham L Lee, Zo ë A Hughes, Nicholas J Brandon, Brandon Whitcher, Douglas HR Blackwood, Andrew M McIntosh, Stephen M Lawrie Source Type: research