Caffeine as symptomatic treatment for Parkinson disease (Cafe-PD): A randomized trial

Conclusion:
Caffeine did not provide clinically important improvement of motor manifestations of PD (Class I evidence). Epidemiologic links between caffeine and lower PD risk do not appear to be explained by symptomatic effects.

Clinicaltrials.gov identifier:
NCT01738178.

Classification of evidence:
This study provides Class I evidence that for patients with PD, caffeine does not significantly improve motor manifestations.

Source: Neurology - October 23, 2017 Category: Neurology Authors: Postuma, R. B., Anang, J., Pelletier, A., Joseph, L., Moscovich, M., Grimes, D., Furtado, S., Munhoz, R. P., Appel-Cresswell, S., Moro, A., Borys, A., Hobson, D., Lang, A. E. Tags: Parkinson's disease/Parkinsonism ARTICLE Source Type: research