Genome ‐wide association studies of bipolar disorder: A systematic review of recent findings and their clinical implications

Abstract AimRecent advances in molecular genetics have enabled assessments of the associations among genetic variants (e.g., single‐nucleotide polymorphisms) and susceptibility for complex diseases, including psychiatric disorders. Specifically, genome‐wide association studies (GWAS), meta‐analyses of the GWAS summary statistics and mega‐analyses, which use raw data (not summary statistics) of GWASs, have provided revolutionary results and identified numerous susceptibility genes or single‐nucleotide polymorphisms. By using several tens of thousands of subjects, >40 genes have been identified as being associated with susceptibility for BD so far. The purpose of this systematic review is to summarize the recent findings of bipolar disorder genome‐wide association studies and discuss their clinical implications.
Source: Psychiatry and Clinical Neurosciences - Category: Neuroscience Authors: Tags: PCN Frontier Review Source Type: research