Design, synthesis, spectroscopic characterization and anti-psychotic investigation of some novel Azo dye/Schiff base/Chalcone derivatives

Publication date: Available online 22 October 2017 Source:Egyptian Journal of Basic and Applied Sciences Author(s): Chandravadivelu Gopi, Vedula Girija Sastry, Magharla Dasaratha Dhanaraju The purpose of the study is to design, synthesise and assess the antipsychotic activity of a set of the novel (5-(10-(3-N, N-Dimethylamino) propyl)-10H-phenothiazine-3-yl)-1,3,4-thiadiazo-2-yl) Azodye/Schiff base/Chalcone derivatives. The newly synthesised compound structure was characterised by FT-IR, 1H NMR, Mass spectroscopy and elemental analysis. Each compound has been shown an excellent anti-psychotic activity in a haloperidol-induced catalepsy metallic bar test. The results found are firmly similar to docking study. Among the synthesised derivatives, compound 2-Amino-6-(3-hydroxy-4-methylphenyl) pyrimidine-4-yl) (7-chloro-10-(3-(N, N-dimethylamino) propyl)-10H-phenothiazine-3-yl) methanone (GC8) exhibiting high potency of catalepsy induction. Therefore, the derivative of GC8 has been considered that a potent anti-psychotic agent among the synthesised compounds. Graphical abstract

Source: Egyptian Journal of Basic and Applied Sciences - October 22, 2017 Category: Science Source Type: research