Contribution of Equilibrative Nucleoside Transporter(s) to Intestinal Basolateral and Apical Transports of Anticancer Trifluridine

In conclusion, ENTs were responsible for intestinal transepithelial permeation by mediating the basolateral efflux of FTD after its uptake by CNT1 from the apical side, resulting in decreases in its intracellular accumulation and intestinal toxicity in humans. ENTs may also partially contribute to the low‐affinity uptake of FTD across the apical membrane along with high‐affinity CNT1.

Source: Biopharmaceutics and Drug Disposition - October 1, 2017 Category: Drugs & Pharmacology Authors: Koichi Takahashi, Kunihiro Yoshisue, Masato Chiba, Takeo Nakanishi, Ikumi Tamai Tags: ORIGINAL PAPER Source Type: research