Intra-cranial Granulomatous Disease in Common Variable Immunodeficiency: Case Series and Review of the Literature

Common variable immunodeficiency (CVID) is typically characterized by hypogammaglobulinemia and often but not always recurrent infections. Paradoxically, 8 –22% of patients with CVID develop granulomatous disease. Granulomata have been described in many organs including the lungs, skin, liver, spleen, kidneys, eyes, lymph nodes and intestines. Data about central nervous system (CNS) involvement in CVID are extremely rare. We aim to describe a case se ries and include an extensive literature review of CNS involvement in CVID to understand the different features and patterns of the disease.

Source: Seminars in Arthritis and Rheumatism - October 20, 2017 Category: Rheumatology Authors: Catherine E. Najem, Jason Springer, Richard Prayson, Daniel A. Culver, James Fernandez, Jinny Tavee, Rula A. Hajj-Ali Source Type: research