Exploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the mu opioid receptor

Conclusion:
Development of such novel chemotypes by targeting position 6 provides valuable insights on ligand-receptor interaction and molecular mode of action, and may aid in identification of opioid therapeutics with enhanced analgesic properties and fewer undesirable effects.

Source: Molecular Pain - July 24, 2014 Category: Molecular Biology Authors: Tanila Ben HaddouDavide MalfaciniGirolamo CaloMario AcetoLouis HarrisJohn TraynorAndrew CoopHelmut SchmidhammerMariana Spetea Source Type: research