Emergence of polymyxin B resistance in a polymyxin B-susceptible KPC-producing Klebsiella pneumoniae causing bloodstream infection in a neutropenic patient during polymyxin B therapy

This study evaluated the molecular mechanisms associated with polymyxin B (PMB) resistance that emerged in a previously PMB-susceptible KPC-2-producing K. pneumoniae during PMB therapy for a bloodstream infection in a neutropenic patient. The first isolate (PMB-susceptible) was obtained while the patient was receiving meropenem and other isolates were recovered from two sets of blood cultures in different dates while the patient was receiving PMB therapy (four of six blood cultures bottles yielded isolates with full PMB resistance).

Source: Diagnostic Microbiology and Infectious Disease - October 19, 2017 Category: Microbiology Authors: Alexandre P. Zavascki, Raquel Girardello, Cibele M. Magagnin, Laura C. Antochevis, Rafael A. Maciel, Jussara K. Palmeiro, Ana C. Gales Source Type: research