Characterization of Type I Interferon Responses in Dengue and Severe Dengue in Children in Paraguay

Dengue is the most rapidly spreading mosquito-borne viral disease worldwide. It is caused by any of the four dengue virus (DENV) serotypes which are transmitted to humans by the bite of Aedes spp. mosquitoes [1,2]. Infection with DENV can remain asymptomatic or cause a spectrum of clinical manifestations of varying severity, ranging from mild fever, formerly known as dengue fever (DF), to a potentially life-threatening disease, characterized by plasma leakage and hemorrhage (dengue hemorrhagic fever [DHF]) leading to hypovolemic shock [3].

Source: Journal of Clinical Virology - October 18, 2017 Category: Virology Authors: Laura B. Talarico, Alana B. Byrne, Sara Amarilla, Dolores Lovera, Cynthia V ázquez, Gustavo Chamorro, Patricio L. Acosta, Adrián Ferretti, Mauricio T. Caballero, Antonio Arbo, Fernando P. Polack Tags: Full length article Source Type: research