Alkaloids of Amaryllidaceae as Inhibitors of Cholinesterases (AChEs and BChEs): An Integrated Bioguided Study

ConclusionsThese results are evidence of the chemical relevance of the Colombian's Amaryllidaceae species for the inhibition of cholinesterases and as potent sources for the palliative treatment of AD. Copyright © 2017 John Wiley & Sons, Ltd. Enzymatic inhibition of cholinesterase (AChE and BChE) is an essential therapeutic target for the treatment of Alzheimer's disease (AD) and cholinesterase inhibitors are the first‐line drugs for it treatment. In this study, a bioguided method for evaluating cholinesterase inhibitory activity is presented, as a powerful tool in the drug discovery from species of the Amaryllidaceae family. These results are evidence of the chemical relevance of the Amaryllidaceae species and as potent sources of compounds for the palliative treatment of AD.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fpca.2736

Source: Phytochemical Analysis - October 18, 2017 Category: Biochemistry Authors: Natalie Cortes, Karina Sierra, Fernando Alzate, Edison H. Osorio, Edison Osorio Tags: Research Article Source Type: research