Uncoupling Tumor-Stroma Interactions in Breast Cancer Patients

Tumor-host interactions are highly regulated and are thought to either favor or impede tumor growth and survival [1,2]. These interactions consist in part on a tight cycling of nutrients and cytokines, and the modulation of signaling pathways between multiple cell types from tumor cells to non-tumor cells (e.g. immune cells, stromal cells). As a metabolic ecosystem is created, the enrichment of nutrients and coupling of the metabolism of stromal cells to that of tumor cells have been shown to support the growth of multiple cancers including breast and ovarian cancers [3,4].
Source: Seminars in Oncology - Category: Cancer & Oncology Authors: Source Type: research