Influence of Contrast Media Dose and Osmolality on the Diagnostic Performance of Contrast Fractional Flow Reserve [Coronary Physiologic Assessment and Imaging]

Conclusions—
The overall accuracy of cFFR is greater than instantaneous wave–free ratio and distal pressure/aortic pressure and not significantly affected by contrast volume and osmolality. However, contrast volume and osmolality do affect the sensitivity and specificity of cFFR.

Clinical Trial Registration—
URL: https://www.clinicaltrials.gov. Unique identifier: NCT02184117.

Source: Circulation: Cardiovascular Interventions - October 17, 2017 Category: Cardiology Authors: Nishi, T., Johnson, N. P., De Bruyne, B., Berry, C., Gould, K. L., Jeremias, A., Oldroyd, K. G., Kobayashi, Y., Choi, D.-H., Pijls, N. H. J., Fearon, W. F., on behalf of the CONTRAST Study Investigators Tags: Coronary Artery Disease Coronary Physiologic Assessment and Imaging Source Type: research