Safety of Oral Dofetilide Reloading for Treatment of Atrial Arrhythmias [Original Articles]

Conclusions:
Although no TdP occurred in patients admitted to reload dofetilide at the same dose as previously tolerated, dosage adjustments or discontinuation was frequent and support the need for hospitalization for dofetilide reloading. Patients admitted for reloading with a higher dose tended to be at higher risk for TdP than patients reloaded at a prior tolerated dose.

Source: Circulation: Arrhythmia and Electrophysiology - October 16, 2017 Category: Cardiology Authors: Cho, J. H., Youn, S. J., Moore, J. C., Kyriakakis, R., Vekstein, C., Militello, M., Poe, S. M., Wolski, K., Tchou, P. J., Varma, N., Niebauer, M. J., Bhargava, M., Saliba, W. I., Wazni, O. M., Lindsay, B. D., Wilkoff, B. L., Chung, M. K. Tags: Arrhythmias, Atrial Fibrillation Original Articles Source Type: research