Action Potential Shortening and Impairment of Cardiac Function by Ablation of Slc26a6 [Original Articles]

Conclusions
Our study provides mechanistic insights into Slc26a6, a unique cardiac electrogenic Cl–/HCO3– transporter in ventricular myocytes, linking the critical roles of Slc26a6 in regulation of pHi, excitability, and contractility. pHi is a critical regulator of other membrane and contractile proteins. Future studies are needed to investigate possible changes in these proteins in Slc26a6–/– mice.

Source: Circulation: Arrhythmia and Electrophysiology - October 12, 2017 Category: Cardiology Authors: Sirish, P., Ledford, H. A., Timofeyev, V., Thai, P. N., Ren, L., Kim, H. J., Park, S., Lee, J. H., Dai, G., Moshref, M., Sihn, C.-R., Chen, W. C., Timofeyeva, M. V., Jian, Z., Shimkunas, R., Izu, L. T., Chiamvimonvat, N., Chen-Izu, Y., Yamoah, E. N., Zhan Tags: Arrhythmias, Electrophysiology, Basic Science Research, Contractile Function, Ion Channels/Membrane Transport Original Articles Source Type: research