Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs [Original Articles]

Conclusions
SK currents play a role in porcine atrial repolarization, and pharmacological inhibition of these with AP14145 demonstrates antiarrhythmic effects in a vernakalant-resistant porcine model of AF. These results suggest SK channel blockers as potentially interesting anti-AF drugs.

Source: Circulation: Arrhythmia and Electrophysiology - October 10, 2017 Category: Cardiology Authors: Diness, J. G., Skibsbye, L., Simo-Vicens, R., Santos, J. L., Lundegaard, P., Citerni, C., Sauter, D. R. P., Bomholtz, S. H., Svendsen, J. H., Olesen, S.-P., Sorensen, U. S., Jespersen, T., Grunnet, M., Bentzen, B. H. Tags: Arrhythmias, Electrophysiology, Animal Models of Human Disease, Ion Channels/Membrane Transport, Remodeling Original Articles Source Type: research