Dose-Dependent Effects of the Myosin Activator Omecamtiv Mecarbil on Cross-Bridge Behavior and Force Generation in Failing Human Myocardium [Original Articles]

Conclusions:
Our findings demonstrate that OM augments force generation but also prolongs the time course of XB transitions to force-bearing states in remodeled HF myocardium, which may extend the systolic ejection time in vivo. Optimal OM dosing is critical for eliciting enhanced systolic function without excessive prolongation of systolic ejection time, which may compromise diastolic filling.

Source: Circulation: Heart Failure - October 13, 2017 Category: Cardiology Authors: Mamidi, R., Li, J., Gresham, K. S., Verma, S., Doh, C. Y., Li, A., Lal, S., dos Remedios, C. G., Stelzer, J. E. Tags: Heart Failure Original Articles Source Type: research