Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3-Targeted Knockin Mice [Original Articles]

Conclusions:
Altogether, we found that (1) autophagy is altered in patients with HCM carrying MYBPC3 mutations, (2) autophagy is impaired in Mybpc3-targeted knockin mice, and (3) activation of autophagy ameliorated the cardiac disease phenotype in this mouse model. We propose that activation of autophagy might be an attractive option alone or in combination with another therapy to rescue HCM caused by MYBPC3 mutations.

Source: Circulation: Heart Failure - October 11, 2017 Category: Cardiology Authors: Singh, S. R., Zech, A. T. L., Geertz, B., Reischmann-Dusener, S., Osinska, H., Prondzynski, M., Kramer, E., Meng, Q., Redwood, C., van der Velden, J., Robbins, J., Schlossarek, S., Carrier, L. Tags: Animal Models of Human Disease, Cell Signaling/Signal Transduction, Heart Failure, Hypertrophy Original Articles Source Type: research