Modelling of thrombin generation under flow in realistic left anterior descending geometries

Coronary artery disease (CAD) is the formation of plaques in the interior of the coronary vessel walls. This condition often leads to thrombus related complications that make CAD the leading cause of mortality worldwide [1]. Thrombus formation in coronary artery is believed to be triggered by the rupture of an atheromatous plaque and subsequent exposure of tissue factor (TF) and collagen. The triggering is followed by a series of biochemical reactions that result in the activation of fibrin by thrombin and the formation of the clot that narrows or blocks the flow in the coronary artery.
Source: Medical Engineering and Physics - Category: Biomedical Engineering Authors: Source Type: research