Assessing daylight & low-light photodynamic therapy efficacy, using biomarkers of photophysical, biochemical and biological damage metrics in situ

Low-fluence daylight photodynamic therapy (PDT) has been shown to reduce pain with similar efficacy of conventional treatments. Three objective assays were performed to assess efficacy of different light treatment strategies: PpIX photobleaching, STAT3 crosslinking, and keratinocyte damage. Of these metrics, STAT3 crosslinking and keratinocyte damage showed a strong correlation to the PpIX-weighted light dose.

Source: Photodiagnosis and Photodynamic Therapy - October 13, 2017 Category: Laser Surgery Authors: Ana Luiza Ribeiro de Souza, Ethan LaRochelle, Kayla Marra, Jason Gunn, Scott C. Davis, Kimberley S. Samkoe, M. Shane Chapman, Edward V. Maytin, Tayyaba Hasan, Brian W. Pogue Source Type: research