Investigating the inhibitory potential of 2-Aminopurine metal complexes against serine/threonine protein kinases from Mycobacterium tuberculosis

Tuberculosis – a disease caused by Mycobacterium tuberculosis (Mtb), is one of the most devastating. The discovery of Ser/Thr protein kinases (STPKs) in Mtb opened a new avenue for developing anti-tubercular inhibitors. The in-vivo inhibitory effects of many metal ions have been demonstrated in literature. But , one of the limitations of metal ions as inhibitors is their inability to traverse the hydrophobic membrane due to polar nature and their propensity for non-specific interactions. To overcome this, we attached a metal ion to 2-A9P – an analog derived from a cell permeable scaffold, 2-Aminopurine (2-AP) which is a known kinase inhibitor.

Source: Tuberculosis - October 13, 2017 Category: Respiratory Medicine Authors: Vaibhav Singh Bais, Balaram Mohapatra, Nadim Ahamad, Sanjana Boggaram, Sandeep Verma, Balaji Prakash Source Type: research