Total Synthesis of ( ) ‐Gracilamine Based on an Oxidative Phenolic Coupling Reaction and Determination of Its Absolute Configuration

AngewchemTotal Synthesis of ( ) ‐Gracilamine Based on an Oxidative Phenolic Coupling Reaction and Determination of Its Absolute Configuration: The enantioselective total synthesis of (+) ‐gracilamine (1) is described. The strategy features a diastereoselective phenolic coupling reaction followed by a regioselective intramolecular aza‐Michael reaction...

Source: Organometallic Current - October 12, 2017 Category: Chemistry Tags: Total synthesis Source Type: blogs