Total Syntheses of ( )- and ( −)-Tetrapetalones A and C

JacsTotal Syntheses of ( )- and ( −)-Tetrapetalones A and C: Described herein are syntheses of the naturally occurring polyketides ( −)-tetrapetalones A and C and their respective enantiomers. The employed strategy involves initial assembly of a maskedN-aryl tetramic acid which is advanced via a highly selective conjugate addition/intramolecular Friedel –Crafts acylation sequence to deliver a key azepine intermediate.

Source: Organometallic Current - October 12, 2017 Category: Chemistry Tags: Total synthesis Source Type: blogs