Glutamate Homeostasis in the Adult Rat Prefrontal Cortex is Altered by Cortical Docosahexaenoic Acid Accrual During Adolescence: An in vivo 1H MRS Study

This study determined the effects of dietary-induced alterations in brain DHA accrual on cortical glutamate homeostasis in the adult rat brain. Adolescent rats were fed a control diet (n=20), a n-3 fatty acid-deficient diet (DEF, n=20), or a fish oil-fortified diet containing preformed DHA (FO, n=20). In adulthood 1H MRS scans were performed with voxels in the prefrontal cortex (PFC) and thalamus.
Source: Psychiatry Research: Neuroimaging - Category: Psychiatry Authors: Source Type: research