Development and  in vitro/in vivo evaluation of a novel benznidazole liquid dosage form using a quality‐by‐design approach

ConclusionQuality by design was a suitable approach to formulate a co‐solvent system of benznidazole. The in vivo studies confirmed the suitability of the optimised such solutions to diminish both parasitaemia and mortality. Thus, this novel alternative should be taken into account for further clinical evaluation in all age ranges.

Source: Tropical Medicine and International Health - October 11, 2017 Category: Tropical Medicine Authors: Higo Fernando Santos Souza, Daniel Real, Dar ío Leonardi, Sandra Carla Rocha, Victoria Alonso, Esteban Serra, Ariel Mariano Silber, Claudio Javier Salomon Tags: Original Article Source Type: research