Sample size estimation for cluster randomized controlled trials

Cluster randomized controlled trials (cRCTs) are commonly used by clinical researchers. The advantages of cRCTs include preventing treatment contamination, enhancing administrative efficiency, convenience, external validity, ethical considerations, and likelihood of increased compliance by participants. However, when designing a cRCT, clinical researchers are faced with challenges, such as cluster units that may not have an equal number of participants within each. In this Technical Note, we discuss approaches for estimating the sample size, while taking into account unequal cluster sizes, and strategies for optimizing the design of cluster trials.

Source: Manual Therapy - October 11, 2017 Category: Physiotherapy Authors: Daniel Cury Ribeiro, Stephan Milosavljevic, J. Haxby Abbott Tags: Technical and measurement report Source Type: research