Enantioselective Phosphine ‐Catalyzed Formal [4 4] Annulation of α,β‐Unsaturated Imines and Allene Ketones: Construction of Eight‐Membered Rings

AngewchemEnantioselective Phosphine ‐Catalyzed Formal [4 4] Annulation of α,β‐Unsaturated Imines and Allene Ketones: Construction of Eight‐Membered Rings: The first highly enantioselective phosphine ‐catalyzed formal [4+4] annulation has been developed. In the presence of amino‐acid‐derived phosphines, the unprecedented [4+4] annulations between benzofuran/indole‐derived...

Source: Organometallic Current - October 11, 2017 Category: Chemistry Tags: organocatalysis Phosphine catalyzed Source Type: blogs