Remote, Late-Stage Oxidation of Aliphatic C –H Bonds in Amide-Containing Molecules

JacsRemote, Late-Stage Oxidation of Aliphatic C –H Bonds in Amide-Containing Molecules: Amide-containing molecules are ubiquitous in natural products, pharmaceuticals, and materials science. Due to their intermediate electron-richness, they are not amenable to any of the previously developedN-protection strategies known to enable remote aliphatic C –H oxidations. Using information gleaned from a systematic study of the main features that makes remote oxidations of amides in peptide settings possible, we developed an imidate salt protecting strategy that employs methyl trifluoromethanesulfonate as a reversible alkylating agent.
Source: Organometallic Current - Category: Chemistry Tags: Fe catalyzed oxidation Source Type: blogs