Hemodialysis Decreases the Concentration of Accumulated Plant Phenols in the Plasma of Patients on Maintenance Dialysis: Influence of Residual Renal Function

Abstract Plant phenols may accumulate in end‐stage kidney disease. The effect of hemodialysis on their plasma concentration remains poorly determined. Contingent on concentration, health‐promoting or noxious effects occur; therefore, we assessed plasma concentration in hemodialyzed patients. In total, 21 maintenance hemodialyzed patients with diuresis < 500 mL per day (with oliguria), nine hemodialyzed patients with diuresis ≥ 500 mL per day (without oliguria) and 31 healthy volunteers were included. Nine phenolic acids were identified with high‐performance liquid chromatography and total polyphenol concentration was determined with the Folin–Ciocalteu method in pre‐ or post‐hemodialysis plasma and pre‐ or intra‐hemodialysis dialysate. The concentration of total polyphenols was 27% higher in pre‐hemodialysis plasma than in that of controls (0.95 ± 0.18 mmol/L [P < 0.0001]). The concentration of total polyphenols was higher in patients with oliguria (1.01 ± 0.17) than in those without (0.84 ± 0.13 mmol/L), despite the former having more intense hemodialysis (Kt/V 1.29 ± 0.31 and 0.77 ± 0.25, respectively). Pre‐hemodialysis phenolic acid concentration in patients undergoing dialysis exceeded reference values by 3 to 34 times (3‐hydroxyphenylacetic acid and vanillic acid, respectively), from 0.69 (dihydrocaffeic acid) to 169.3 μmol/L (hippuric acid). The concentration of six phenolic acids (3‐hydroxyhippuric, caffeic, dihyd...
Source: Therapeutic Apheresis and Dialysis - Category: Hematology Authors: Tags: Original Article Source Type: research