[Comment] Pathology and hippocampal atrophy in Alzheimer's disease

Over time, reduced hippocampal volume results in an amnestic syndrome, a core feature of Alzheimer's disease.1 Damage to the hippocampus is incorporated into the pathological criteria for Alzheimer's disease, with two regionally separable pathological features required: at least some neurofibrillary tangles in the hippocampus, and β-amyloid deposition and moderate neuritic infiltrate in association cortices.2 The severity of hippocampal tangle formation at clinical onset can be very variable (from some neurons to nearly all neurons involved).

Source: Lancet Neurology - October 11, 2017 Category: Neurology Authors: Glenda Halliday Tags: Comment Source Type: research