Critical features and challenges associated with imaging in patients undergoing cancer immunotherapy

Manipulating an individual ’s immune system through immune checkpoint blockade is revolutionizing the paradigms of cancer treatment. Peculiar patterns and kinetics of response have been observed with these new drugs, rendering the assessment of tumor burden particularly challenging in cancer immunotherapy. The mechanisms of action for immune checkpoint blockade, based upon engagement of the adaptive immune system, can generate unusual response patterns, including pseudoprogression, hyperprogression, atypical and delayed responses.
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Tags: Review article Source Type: research