Mammalian target of rapamycin signaling is a mechanistic link between increased endoplasmic reticulum stress and autophagy in the placentas of pregnancies complicated by growth restriction

Increased endoplasmic reticulum (ER) stress and autophagy have been noted in the placentas of pregnancies complicated by idiopathic intrauterine growth restriction (IUGR); however, the cause of these phenomena remains unclear. We surmised that oxygen-glucose deprivation (OGD) may increase ER stress and autophagy and that mammalian target of rapamycin (mTOR) signaling is involved in regulating placental ER stress and autophagy in pregnancies complicated by IUGR.

Source: Placenta - October 9, 2017 Category: Reproduction Medicine Authors: Tai-Ho Hung, T'sang-T'ang Hsieh, Chung-Pu Wu, Meng-Jen Li, Yi-Lin Yeh, Szu-Fu Chen Source Type: research