Impaired TNF, IL-1 β, and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individuals

IFN- γ and TNF play critical roles in the control of Mycobacterium tuberculosis infection. Despite leading to an exaggerated production of inflammatory cytokines, HTLV-1 infection increases the risk of developing tuberculosis (TB). However, the immune mechanisms accounting for this phenomenon are still unclear. The aim of this study was to evaluate immunological aspects of the HTLV-1/M. tuberculosis co-infection. In this cross-sectional study, the levels of TNF, IL-1β, and IL-17 were determined by ELISA in the supernatants of either unstimulated or tuberculin purified protein derivative (PPD) sti mulated peripheral blood mononuclear cells.

Source: Tuberculosis - October 9, 2017 Category: Respiratory Medicine Authors: Nat ália B. Carvalho, Maria de Lourdes Bastos, Anselmo S. Souza, Eduardo M. Netto, Sérgio Arruda, Silvane B. Santos, Edgar M. Carvalho Source Type: research