Antinociceptive effects of epidural magnesium sulphate alone and in combination with morphine in dogs

Conclusion and clinical relevanceEpidural MgSO4 produced an antinociceptive effect characterised by an increase in the mechanical thresholds of similar magnitude to that produced by epidural morphine, compared with the control group, without causing any motor deficits. No potentiation of morphine antinociception was observed. The onset and offset times of antinociception could not be clearly established. To what extent these results can be extrapolated to clinical cases requires further investigation.

Source: Veterinary Anaesthesia and Analgesia - July 1, 2014 Category: Veterinary Research Authors: Anne Bahrenberg, Brighton T Dzikiti, Geoffrey T Fosgate, Frik G Stegmann, Sabine P Tacke, Eva Rioja Tags: Research Paper Source Type: research