Rapid changes in serum cytokines and chemokines in response to inactivated influenza vaccination

ConclusionsSerum cytokines changed rapidly following TIV and generally peaked at 24 hours. TIV‐induced reductions in IL‐8 occurred later (44h) and were sustained for 2 weeks. An outlier response coincided with the only moderate side effects to the vaccine. These data suggest that early cytokine/chemokine responses may provide additional insight into the pathogenesis of adverse events and immune reactivity to vaccination.This article is protected by copyright. All rights reserved.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Firv.12509

Source: Influenza and Other Respiratory Viruses - September 1, 2017 Category: Virology Authors: Kawsar R. Talaat, Neal A. Halsey, Amber B. Cox, Christian L. Coles, Anna P. Durbin, Amritha Ramakrishnan, Jay H. Bream Tags: Original Article Source Type: research