Dopamine reduces cell surface Na+/H+ exchanger-3 protein by decreasing NHE3 exocytosis and cell membrane recycling

In conclusion, among the many mechanisms by which DA reduces apical membrane NHE3 and induces proximal tubule natriuresis, one additional mechanism is inhibition of exocytotic insertion and reinsertion of NHE3 in the apical cell surface.

Source: AJP: Renal Physiology - October 9, 2017 Category: Urology & Nephrology Authors: Hu, M. C., Bobulescu, I. A., Quinones, H., Gisler, S. M., Moe, O. W. Tags: RESEARCH ARTICLE Source Type: research