Topically Applied Epsilon-Aminocaproic Acid Reduces Blood Loss and Length of Hospital Stay After Total Knee Arthroplasty

Total knee arthroplasty (TKA) is associated with significant blood loss in the perioperative period.1 Blood loss may lead to swelling, hematoma formation, postoperative stiffness, and prolonged drainage, which can delay rehabilitation, functional recovery, and hospital discharge and increase health care costs.2 Postoperative stiffness with delayed rehabilitation can be caused by hidden blood loss. Hidden blood loss is caused by hyperfibrinolysis and accumulates in the anatomic third space.3 The peak of hyperfibrinolysis occurs 6 hours postoperatively and lasts for up to 18 hours.4 Systemic

Source: Research in gerontological nursing - October 3, 2017 Category: Geriatrics Authors: Robert A. Harper, MD Source Type: research