Chapter 14 Neurotoxicology and drug-related disorders

Publication date: 2017 Source:Handbook of Clinical Neurology, Volume 145 Author(s): Serge Weis, Andreas Büttner Neuropsychiatric disorders caused by toxic substances pose a great diagnostic challenge due to the large variety of changes caused in the central and peripheral nervous system. The pathogenetic mechanisms at work are multifaceted and partly not solved. In human drug abusers (cannabis, opiates, cocaine, amphetamines, methamphetamine and “designer drugs”), a broad spectrum of central nervous system alterations are observed including infarction, intracerebral and subarachnoidal hemorrhage, hypoxic-ischemic leukoencephalopathy, infections, neuronal loss, specific astroglial and microglial reaction patterns, and vascular changes, including the endothelial cell as well as the basal lamina.
Source: Handbook of Clinical Neurology - Category: Neurology Source Type: research