Comprehensive Detection of Viruses in Pediatric Patients with Acute Liver Failure Using Next-Generation Sequencing

Pediatric acute liver failure (PALF) is a rare disease in which liver function is rapidly destroyed accompanied with coagulopathy and with or without altered mentation. In Japan, approximately 10 cases are annually registered and the estimated frequency is 20 cases per year [1]. The prognosis of PALF is severe; more than 70% of cases undergo liver transplantation with an estimated survival rate of 50 –70% [1]. Patients are required to take immunosuppressive agents for a long time after liver transplantation, thus alternative treatments are needed.

Source: Journal of Clinical Virology - October 3, 2017 Category: Virology Authors: Takako Suzuki, Jun-ichi Kawada, Yusuke Okuno, Satoshi Hayano, Kazuhiro Horiba, Yuka Torii, Yoshiyuki Takahashi, Syuichiro Umetsu, Tsuyoshi Sogo, Ayano Inui, Yoshinori Ito Tags: Full length article Source Type: research