Chronic hindbrain administration of oxytocin is sufficient to elicit weight loss in diet-induced obese rats

We report that chronic 4V infusion of OT into two distinct rat models recapitulates the effects of 3V OT to ameliorate DIO by reducing fat mass. While reduced food intake contributes to this effect, our finding that 4V OT also increases BAT thermogenesis suggests that increased energy expenditure may contribute as well. Collectively, these findings support the hypothesis that, in DIO rats, OT action in the hindbrain evokes sustained weight loss by reducing energy intake and increasing BAT thermogenesis.

Source: AJP: Regulatory, Integrative and Comparative Physiology - October 1, 2017 Category: Physiology Authors: Roberts, Z. S., Wolden-Hanson, T., Matsen, M. E., Ryu, V., Vaughan, C. H., Graham, J. L., Havel, P. J., Chukri, D. W., Schwartz, M. W., Morton, G. J., Blevins, J. E. Tags: Research Article Source Type: research