Combined morphological, immunohistochemical and genetic analyses of medulloepithelioma in the posterior cranial fossa

We report a case of medulloepithelioma in the posterior cranial fossa that was diagnosed by both morphological and genetic analyses based on this classification. A 10‐month‐old girl was admitted to our hospital with consciousness disturbance and vomiting. Neuroimaging revealed a partially calcified mass and cyst formation in the posterior cranial fossa. Partial resection of the tumor was performed and histological findings revealed multilayered rosettes with LIN28A staining, but genetic analysis showed no amplification of the C19MC microRNA cluster at 19q14.32. Therefore, we diagnosed the tumor as medulloepithelioma belonging to other CNS embryonal tumors. The patient was immediately treated with systemic high‐dose chemotherapy. Follow‐up neuroimaging 10 months later showed no signs of recurrence. Medulloepitheliomas are difficult to diagnose by routine HE staining and require combined morphological, immunohistochemical and genetic analyses to provide an accurate diagnosis.

Source: Neuropathology - October 1, 2017 Category: Neurology Authors: Kosuke Kusakabe, Shohei Kohno, Akihiro Inoue, Toshimoto Seno, Sachiko Yonezawa, Kyoko Moritani, Yosuke Mizuno, Mie Kurata, Riko Kitazawa, Hisamichi Tauchi, Hideaki Watanabe, Shinji Iwata, Junko Hirato, Takeharu Kunieda Tags: Case Report Source Type: research