Idelalisib plus rituximab is effective in systemic AL amyloidosis secondary to chronic lymphocytic leukaemia
Abstract
Light chain amyloidosis is characterized by the progressive deposition of immunoglobulin light chains into the extracellular tissue, leading to organ dysfunction. Usually, it is associated with an underlying clonal plasma cell dyscrasia and rarely with chronic lymphocytic leukaemia. Herein, we described the first report of a patient with relapsed chronic lymphocytic leukaemia harbouring TP53 abnormalities who developed, histologically proven, systemic light chain amyloidosis who was treated with the PI3K inhibitor, idelalisib, and rituximab. Unfortunately, the patient had sudden death during sleep, likely caused by arrhythmia secondary to amyloid cardiomyopathy. Idelalisib was at least effective in reducing secretory free light chain, chronic lymphocytic leukaemia burden, and to improve the survival of patient.
Source: Hematological Oncology - Category: Hematology Authors: Andrea Visentin, Chiara Briani, Silvia Imbergamo, Federica Frezzato, Annalisa Angelini, Marny Fedrigo, Mario Cacciavillani, Sara Altinier, Francesco Piazza, Gianpietro Semenzato, Fausto Adami, Livio Trentin Tags: LETTER TO THE EDITOR Source Type: research
More News: Amyloidosis | Arrhythmia | Cancer & Oncology | Cardiology | Cardiomyopathy | Chronic Leukemia | Chronic Lymphocytic Leukemia | Heart | Hematology | Leukemia | Rituxan | Sleep Disorders | Sleep Medicine