Two cases of laboratory-confirmed exposure to 25B-NBOMe

25I-NBOMe blotter paper 3 out of 5 stars Two cases of severe intoxication associated with analytically confirmed use of the novel psychoactive substances 25B-NBOMe and 25C-NBOMe. Tang MHY et al. Clin Toxicol 2014 Jun;52:561-565. Abstract The NBOMe series of drugs are substituted phenethylamines. They act as agonists at both the 5-HT2A receptors and the α-receptors. Because of these actions, they can cause both hallucinations (5-HT2A  effects) and sympathomimetic toxidrome (α effects.) Since these drugs are so potent, they are often sold in the form of impregnated blotter paper. This paper, from Hong Kong, describes 2 laboratory-confirmed cases of 25B-NBOMe toxicity. One patient also had 25C-NBOMe in his urine. Given the basic toxicology of these compounds, the patients’ signs and symptoms were not surprising. Both ad mydriasis, agitation, hypertension, tachycardia, hyperthermia, diaphoresis, and altered mental status, One patient had seizure activity and was intubated. The other developed rhabdomyolysis and renal impairment.  Treatment included basic supportive care, fluids, and benzodiazepines. [Photograph of blotter paper, seized in Austria in April 2013, from Belgian Early Warning System on Drugs. The blotter paper had been sold as LSD but found to contain 25I-NBOMe] Related posts: NBOME — it’s not your father’s LSD Case series: 7 patients with confirmed exposure to hallucinogenic stimulant 25I-NBOMe (“N-bomb”) 25I-NBOMe: a dangerou...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical 25B-NBOMe 25C-NBOME 25I-NBOMe blotter paper hallucinogenics sympathomimetic toxidrome Source Type: news