Aliskiren increases aquaporin-2 expression and attenuates lithium-induced nephrogenic diabetes insipidus

In conclusion, the direct renin inhibitor aliskiren upregulates AQP2 protein expression in inner medullary collecting duct principal cells and prevents lithium-induced nephrogenic diabetes insipidus likely via cAMP-PKA pathways.

Source: AJP: Renal Physiology - October 1, 2017 Category: Urology & Nephrology Authors: Lin, Y., Zhang, T., Feng, P., Qiu, M., Liu, Q., Li, S., Zheng, P., Kong, Y., Levi, M., Li, C., Wang, W. Tags: RESEARCH ARTICLE Source Type: research