Vitamin D attenuates sphingosine-1-phosphate (S1P)-Mediated inhibition of extravillous trophoblast migration

Failure of trophoblast invasion and remodelling of maternal blood vessels leads to the pregnancy complication pre-eclampsia (PE). In other systems, the sphingolipid, sphingosine-1-phosphate (S1P), controls cell migration therefore this study determined its effect on extravillous trophoblast (EVT) function.

Source: Placenta - September 30, 2017 Category: Reproduction Medicine Authors: Melissa Westwood, Khiria Al-Sagihir, Sarah Finn-Sell, Cherlyn Tan, Elizabeth Cowley, St éphane Berneau, Daman Adlam, Edward D. Johnstone Source Type: research