Minocycline increases firing rates of accumbal neurons and modifies the effects of morphine on neuronal activity

In conclusion, our findings indicated that minocycline modifies morphine‐induced decreases in the firing rates of NAc neurons in the reinstatement phase. Intra‐LV injection of minocycline increases NAc neural activity. Intra‐LV infusion of minocycline modifies the inhibitory effects of morphine on NAc neurons. Subchronic minocycline infusions during extinction phase dose not modify the inhibitory effects of morphine on NAc neurons.
Source: Addiction Biology - Category: Addiction Authors: Tags: Original Article Source Type: research