Effects of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice

Conclusions:
Peroral arsenic has little effect on local airway immune responses to bacteria but compromises respiratory epithelial barrier integrity, increasing systemic translocation of inhaled pathogens and small molecules. https://doi.org/10.1289/EHP1878

Received: 09 March 2017
Revised: 14 August 2017
Accepted: 16 August 2017
Published: 28 September 2017
Address correspondence to M.B. Fessler, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., P.O. Box 12233, Maildrop D2-01, Research Triangle Park, NC 27709 USA. Telephone: [phone]. Email: [e-mail]
*Current address: UNC School of Medicine, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, CB7035, Genetic Medicine Building, Chapel Hill, North Carolina 27599.
†Current address: East Carolina Diabetes and Obesity Institute, Dept. of Physiology, East Carolina University, ECHI 4101C, Greenville, North Carolina 27834.
The authors declare they have no actual or potential competing financial interests.
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Source: EHP Research - September 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research