Synthesis, antibacterial and molecular docking studies of new benzimidazole derivatives

Publication date: Available online 28 September 2017 Source:Egyptian Journal of Basic and Applied Sciences Author(s): Kumaraswamy Gullapelli, G. Brahmeshwari, M. Ravichander, Uma Kusuma The new analogs of benzimidazole fused heterocyclic compounds such as triazinane and oxadiazinanes were synthesised by classical amino methylation with different aryl-N,N′ unsymmetrical thioureas. The antibacterial activity of triazinane and oxadiazinane compounds have been assessed with zone of inhibition by well diffusion method using a panel of selected gram positive and gram negative bacterial strains and which have showed good activity. The synthesised molecules were subjected to molecular docking studies with two proteins, namely topoisomerase II (PDB ID: 1JIJ) and DNA gyrase subunit b (PDB ID: 1KZN). The molecular docking studies are supporting the antibacterial activity exhibiting high inhibition constant and binding energy.

Source: Egyptian Journal of Basic and Applied Sciences - September 28, 2017 Category: Science Source Type: research